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COVID-19

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The first known case was identified in Wuhan, China, in December 2019. The disease has since spread worldwide, leading to an ongoing pandemic.Symptoms of COVID-19 are variable, but often include fever, cough, headache, fatigue, breathing difficulties, and loss of smell and taste. Symptoms may begin one to fourteen days after exposure to the virus. At least a third of people who are infected do not develop noticeable symptoms. Of those people who develop symptoms noticeable enough to be classed as patients, most (81%) develop mild to moderate symptoms (up to mild pneumonia), while 14% develop severe symptoms (dyspnea, hypoxia, or more than 50% lung involvement on imaging), and 5% suffer critical symptoms (respiratory failure, shock, or multiorgan dysfunction). Older people are at a higher risk of developing severe symptoms. Some people continue to experience a range of effects (long COVID) for months after recovery, and damage to organs has been observed. Multi-year studies are underway to further investigate the long-term effects of the disease.COVID-19 transmits when people breathe in air contaminated by droplets and small airborne particles containing the virus. The risk of breathing these in is highest when people are in close proximity, but they can be inhaled over longer distances, particularly indoors.

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COVID-19 pandemic

The COVID-19 pandemic, also known as the coronavirus pandemic, is an ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The novel virus was first identified in the Chinese city of Wuhan in December 2019; a lockdown in Wuhan and other cities in surrounding Hubei failed to contain the outbreak, and it quickly spread to other parts of mainland China and around the world. The World Health Organization (WHO) declared a Public Health Emergency of International Concern on 30 January 2020, and a pandemic on 11 March 2020. Multiple variants of the virus have emerged and become dominant in many countries since 2021, with the Alpha, Beta, Gamma, Delta and Omicron variants being the most virulent. As of 5 December 2021, more than 265 million cases and 5.25 million deaths have been confirmed, making the pandemic one of the deadliest in history. COVID-19 symptoms range from none to life-threatening. Severe illness is more likely in elderly patients and those with certain underlying medical conditions. Transmission of COVID-19 occurs when people breathe in air contaminated by droplets and small airborne particles. The risk of breathing these in is highest when people are in close proximity, but the virus can transmit over longer distances, particularly indoors and in poorly ventilated areas. Transmission can also occur, rarely, via contaminated surfaces or fluids.

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Clitoris

The clitoris ( (listen) or (listen)) is a female sex organ present in mammals, ostriches and a limited number of other animals. In humans, the visible portion – the glans – is at the front junction of the labia minora (inner lips), above the opening of the urethra. Unlike the penis, the male homologue (equivalent) to the clitoris, it usually does not contain the distal portion (or opening) of the urethra and is therefore not used for urination. In most species, the clitoris lacks any reproductive function. While few animals urinate through the clitoris or use it reproductively, the spotted hyena, which has an especially large clitoris, urinates, mates, and gives birth via the organ. Some other mammals, such as lemurs and spider monkeys, also have a large clitoris.The clitoris is the human female's most sensitive erogenous zone and generally the primary anatomical source of human female sexual pleasure. In humans and other mammals, it develops from an outgrowth in the embryo called the genital tubercle. Initially undifferentiated, the tubercle develops into either a penis or a clitoris during the development of the reproductive system depending on exposure to androgens (which are primarily male hormones). The clitoris is a complex structure, and its size and sensitivity can vary. The glans (head) of the human clitoris is roughly the size and shape of a pea and is estimated to have about 8,000 sensory nerve endings.Sexological, medical, and psychological debate have focused on the clitoris, and it has been subject to social constructionist analyses and studies.

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EMedicine

eMedicine is an online clinical medical knowledge base founded in 1996 by Scott Plantz MD FAAEM, and Jonathan Adler MD MS FACEP FAAEM, a computer engineer Jeffrey Berezin MS. The fundamental concept was to create a large repository of professional level medical content that could be both updated and accessed continuously to assist in clinical care and physician education. The eMedicine website consists of approximately 6,800 medical topic review articles, each of which is associated with one of 62 clinical subspecialty "textbooks". Pediatrics, for example, has 1,050 articles organized into 14 subspecialty "textbooks" (Pediatric endocrinology, genetics, cardiology, pulmonology, etc.); the emergency medicine volume has 630 articles and internal medicine has nearly 1,400 articles. If the remainder of the specialty textbooks (e.g., Neurology, Orthopedics, Ophthalmology, etc.) are added to the total 6800+ articles were created in eMedicine. In addition, the knowledge base includes over 25,000 clinically multimedia files (e.g., photographs, imaging studies, audio files, video files). To create this online content over 11,000 board certified healthcare specialists (95%+ physicians, 95%+ US based) were recruited and managed in a first generation, proprietary learning management system (LMS). If printed out in hardcopy form, the system's content would total over 1 million pages. Each article is authored by board certified specialists in the subspecialty to which the article belongs and undergoes three levels of physician peer-review, plus review by a Doctor of Pharmacy. The article's authors are identified with their current faculty appointments. Each article is updated yearly, or more frequently as changes in practice occur, and the date is published on the article.

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Methamphetamine

Methamphetamine (contracted from N-methylamphetamine) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamphetamine was discovered in 1893 and exists as two enantiomers: levo-methamphetamine and dextro-methamphetamine. Methamphetamine properly refers to a specific chemical substance, the racemic free base, which is an equal mixture of levomethamphetamine and dextromethamphetamine in their pure amine forms. It is rarely prescribed over concerns involving human neurotoxicity and potential for recreational use as an aphrodisiac and euphoriant, among other concerns, as well as the availability of safer substitute drugs with comparable treatment efficacy. Dextromethamphetamine is a stronger CNS stimulant than levomethamphetamine. Both racemic methamphetamine and dextromethamphetamine are illicitly trafficked and sold owing to their potential for recreational use. The highest prevalence of illegal methamphetamine use occurs in parts of Asia and Oceania, and in the United States, where racemic methamphetamine and dextromethamphetamine are classified as schedule II controlled substances. Levomethamphetamine is available as an over-the-counter (OTC) drug for use as an inhaled nasal decongestant in the United States. Internationally, the production, distribution, sale, and possession of methamphetamine is restricted or banned in many countries, due to its placement in schedule II of the United Nations Convention on Psychotropic Substances treaty. While dextromethamphetamine is a more potent drug, racemic methamphetamine is illicitly produced more often due to the relative ease of synthesis and regulatory limits of chemical precursor availability.

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Michael Jackson

Michael Joseph Jackson (August 29, 1958 – June 25, 2009) was an American singer, songwriter and dancer. Dubbed the "King of Pop", he is regarded as one of the most significant cultural figures of the 20th century. Over a four-decade career, his contributions to music, dance and fashion, along with his publicized personal life, made him a global figure in popular culture. Jackson influenced artists across many music genres; through stage and video performances, he popularized complicated dance moves such as the moonwalk, to which he gave the name, as well as the robot. He is the most awarded music artist in history. The eighth child of the Jackson family, Jackson made his professional debut in 1964 with his elder brothers Jackie, Tito, Jermaine and Marlon as a member of the Jackson 5 (later known as the Jacksons). Jackson began his solo career in 1971 while at Motown Records. He became a solo star with his 1979 album Off the Wall. His music videos, including those for "Beat It", "Billie Jean" and "Thriller" from his 1982 album Thriller, are credited with breaking racial barriers and transforming the medium into an artform and promotional tool. He helped propel the success of MTV and continued to innovate with videos for the albums Bad (1987), Dangerous (1991) and HIStory: Past, Present and Future, Book I (1995).

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Salma Hayek

Salma Hayek Pinault (; Spanish: [ˈsalma ˈxaʝek]; born Salma Valgarma Hayek Jiménez; September 2, 1966) is a Mexican and American actress and film producer. She began her career in Mexico starring in the 1989 telenovela Teresa, as well as the 1995 film El Callejón de los Milagros (Miracle Alley), for which she received an Ariel Award nomination. She rose to prominence with appearances in films such as Desperado (1995), From Dusk till Dawn (1996), Wild Wild West, and Dogma (both 1999). Hayek became well known after her role in the 2002 biographical film Frida, a film which she co-produced and starred in as Mexican painter Frida Kahlo. For her performance, she received a nomination for the Academy Award for Best Actress, becoming the first Mexican actress nominated in that category, in addition to nominations for the Golden Globe Award, Screen Actors Guild Award, and British Academy Film Award for Best Actress. The film was widely praised and became a critical and commercial success. Hayek won the Daytime Emmy Award for Outstanding Directing in a Children/Youth/Family Special for The Maldonado Miracle in 2004, and received a Primetime Emmy Award nomination for Outstanding Guest Actress in a Comedy Series after guest-starring in the ABC television comedy-drama Ugly Betty in 2007. She also guest-starred on the NBC comedy series 30 Rock from 2009 to 2013. In 2017, she was nominated for an Independent Spirit Award for her role in Beatriz at Dinner.Hayek's subsequent films include Grown Ups (2010), Puss in Boots (2011), Grown Ups 2 (2013), Tale of Tales (2015), Sausage Party (2016), The Hitman's Bodyguard (2017), Like a Boss (2020), Eternals and House of Gucci (both 2021). Hayek has been married since 2009 to French business magnate François-Henri Pinault, with whom she has a daughter.

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Serena Williams

Serena Jameka Williams (born September 26, 1981) is an American professional tennis player, fashion designer, philanthropist, and movie producer. She has won 23 Grand Slam singles titles, the most by any player in the Open Era, and the second-most of all time behind Margaret Court (24). The Women's Tennis Association (WTA) ranked her singles world No. 1 on eight separate occasions between 2002 and 2017. On her sixth occasion, she held the ranking for 186 consecutive weeks, tying the record set by Steffi Graf. In total, she has been WTA No. 1 for 319 weeks, which ranks third in the Open Era behind Graf and Martina Navratilova. She is the only American player, male or female, to win more than 20 slams. Williams is widely regarded to be one of the greatest female tennis players of all time. She holds the most Grand Slam titles in singles, doubles, and mixed doubles combined among active players.

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